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Naldemedine could improve defecation frequency in sufferers with most cancers and poor efficiency standing who’ve opioid-induced constipation, in line with a multicenter, retrospective examine revealed in Journal of Palliative Drugs.
Researchers collected digital medical information for sufferers at 10 Japanese establishments from June 7, 2017 to August 31, 2019.
Sufferers met inclusion standards for the examine if they’d most cancers with poor efficiency standing (outlined as an Japanese Cooperative Oncology Group Efficiency Standing [ECOG-PS] rating ≥ 3); have been hospitalized for greater than 7 days earlier than and after naldemedine administration, throughout which era defecation frequency was measured; and used naldemedine concomitantly with opioids (N=71).
The variety of defecations through the 1-week interval earlier than naldemedine administration was thought of baseline information. Modifications in defecation frequency earlier than and after initiating naldemedine remedy have been evaluated for all sufferers.
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This examine demostrated that naldemedine is efficacious and could be feasibly administered in a medical follow setting to deal with most cancers sufferers with poor PS; it ought to due to this fact be thought of for the remedy of OIC in such sufferers.
The sufferers got 0.2 mg of naldemedine with opioids as soon as each day and have been thought of responders if defecation frequency elevated to three or extra instances per week.
Of the 71 sufferers, 66.1% have been responders (95% CI, 54.5%–76.1%). Defecation frequency elevated considerably within the total inhabitants after naldemedine initiation (P < .0001) and in these whose baseline defecation frequency measured at lower than 3 instances every week earlier than administration of naldemedine (P < .0001).
Diarrhea was the commonest antagonistic occasion noticed within the cohort.
Limitations of the examine included its retrospective design and the subjective nature of the ECOG-PS evaluation. As well as, the examine lacked information on laxative use.
“This examine demonstrated that naldemedine is efficacious and could be feasibly administered in a medical follow setting to deal with most cancers sufferers with poor PS; it ought to due to this fact be thought of for the remedy of [opioid-induced constipation] in such sufferers. Additional validation in medical follow is critical,” the examine authors concluded.
References:
Fujita Y, Imai H, Hiruta E, et al. Efficacy and security of naldemedine administration for opioid-induced constipation in most cancers sufferers with poor efficiency standing. J Palliat Med. Printed on-line March 31, 2023. doi:10.1089/jpm.2022.0495
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