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No matter vaccination standing, adults hospitalized for COVID-19 an infection are at elevated danger for acute thromboembolism, in keeping with examine outcomes introduced at IDWeek 2022, held from October 19 to 23, in Washington, DC.
Researchers performed a retrospective cohort examine between March 2020 and March 2022 to evaluate the consequences of COVID-19 vaccination standing on the incidence of acute thromboembolism amongst adults hospitalized with COVID-19 an infection. All included sufferers have been receiving standard-dose thromboprophylaxis, and none have been admitted to an intensive care unit (ICU). The first end result was acute thromboembolism incidence, and a number of logistic regression was used to id related danger components.
A complete of 1428 sufferers have been included within the evaluation, of whom 185 (13%) have been vaccinated and 1243 (87%) have been unvaccinated in opposition to COVID-19 an infection. Of the vaccinated and unvaccinated sufferers, the imply age was 68.1 and 61.2 years, 53.5% and 53.5% have been males, and 10.3% and 9.6% have been Black, respectively. Vital variations have been famous between the vaccinated vs unvaccinated teams in regard to comorbidities. These included the share of sufferers with diabetes (45.4% vs 36.0%; P =.014), coronary heart failure (24.3% vs 7.4%; P <.0001), atrial fibrillation (16.2% vs 7.6%; P <.0001), most cancers (18.4% vs 8.0%; P <.0001), power kidney illness (29.7% vs 16.6%; P <.0001), and immunodeficiency (14.6% vs 7.6%; P =.001).
There was an elevated incidence of acute thromboembolism noticed amongst vaccinated vs unvaccinated sufferers (7.0% vs 3.9%). Nonetheless, after performing a number of logistic regression, this discovering was not statistically important (adjusted odds ratio [aOR], 1.35; 95% CI, 0.67-2.58; P =.38).
Additional evaluation between vaccinated vs unvaccinated sufferers confirmed the danger for acute thromboembolism was considerably related to older age (68 vs 61 years; OR, 1.03; 95% CI, 1.01-1.05; P =.01) and coronary heart failure (24% vs 7%; OR, 2.84; 95% CI, 1.35-6.00; P =.006).
In regard to the speed of mortality, no important variations have been famous between vaccinated vs unvaccinated sufferers (3.8% vs 4.8%; OR, 0.79; 95% CI, 0.35-1.69; P =.56).
Primarily based on these findings, “Choices to anticoagulate non-ICU sufferers hospitalized with acute COVID-19 infections could not want to contemplate COVID[-19] vaccination standing in as a part of medical determination making,” the researchers concluded.
Disclosures: Some authors declared affiliations with biotech, pharmaceutical, and/or gadget corporations. Please see the unique reference for a full checklist of disclosures.
This text initially appeared on Infectious Illness Advisor.
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